Likewise, a rapid and significant increase in EPC numbers, detected by utilising 5 different approaches (CD34+, D34+/CD117+, CD34+/CXCR4+, CD34+/CD38+ and CD34+/CD45+), has been reported after the onset of ischemia in acute myocardial infarction [22,38]. This evidence concerns the gene CD34 and ischemia.