Histopathologic analysis of lesion tissues of CL patients show mixed granulomas consisting of macrophages, lymphocytes, epitheloid, and plasma cells; and chemokines such as CXCL-9, MCP-1, MIP-1α and MIP-1β are the potent chemoattractant of T cells, monocyte and macrophages. The gene discussed is CCL4; the disease is Granuloma.