Of the 49 cases, 17 (34.7%) were associated with classical lobular carcinoma in situ, 6 (32%) cases exhibited >50% EZH2-positive nuclei of both lobular carcinoma in situ and ILC, but 2 (12%) cases exhibited completely EZH2-negative nuclei in lobular carcinoma in situ and <5% EZH2-positive nuclei in ILC. Here, EZH2 is linked to breast carcinoma.