Since the expression of CSC-related markers has been shown to portend increased aggressiveness in some tumors such as pancreatic adenocarcinoma [21] and non small cell lung cancer [22] and since ALDH1 seems to be a reliable marker for CSCs, we evaluated whether ALDH1 expression could be associated with local pathologic tumor characteristics and clinical outcome in renal cell carcinoma. Here, ALDH1A1 is linked to neoplasm.