Using multiple sequence alignment to identify structurally and functionallyequivalent residues across the protein family, we observed that one of the KLHL3 variants reportedpreviously to be associated with FHHt [14,15] (KLHL3 p.R384W) co-locates with a reported disease-causingvariant in another member of the protein family KBTBD13 p.R248S {where KBTBD13 is kelch repeat andBTB [BR-C (Broad Complex), ttk (tramtrack) and bab (bric a brac)] (POZ) domain-containing 13}, whichis associated with nemalin myopathy [26]. The gene discussed is KLHL3; the disease is nemaline myopathy.