AKT is an integral part of a pivotal signaling pathway, which promotes tumor cell proliferation and protects cells from apoptosis and senescence via a variety of downstream pathways, such as mammalian target of rapamycin (mTOR), glycogen synthase kinase 3 (GSK-3) and Forkhead box O (FOXO) [32,43]. The gene discussed is MTOR; the disease is neoplasm.