KLK4 and type 2 diabetes mellitus: Moreover, in spite of previous studies showing that individuals with T2D exhibit PEH when exercising at intensities around LT [7,8,15], Motta et al. [6] found that subjects with T2D exhibit lower plasma kallikrein activity (PKA) compared to healthy individuals, suggesting that lower NO release and reduced endothelium-dependent vasodilation would be occurring in response to exercise for this population.