HS3ST2 mRNA levels were significantly higher in normal tissues than in tumor tissues (P = 0.0004, Wilcoxon signed-rank test; Figure 5A), and negative correlation was observed between expression and methylation of the HS3ST2 in 26 tumor tissues (ρ = -0.51, P = 0.009, Spearnman’s rank correlation; Figure 5B). Here, HS3ST2 is linked to neoplasm.