HLA-DRB1 (*01, *03, *0405, *07, *08, *0801 and *0803) were found to predisposition individuals to PBC, and the pooled results were 1.26 (1.05–1.51), 1.38 (1.16–1.65), 1.43 (1.16–1.76), 2.03 (1.29–3.21) and 1.47 (1.27–1.70), 2.30 (1.76–3.00) and 2.48 (1.60–3.84), 3.23 (2.22–4.70), and 2.64 (1.55–4.51), 3.00 (1.89–4.76), respectively (Figure 3; Table 2). This evidence concerns the gene HLA-DRB1 and primary biliary cholangitis.