Also, 13 of those variants were found to be significant risk factors for PBC including DR8, HLA-DQB1 (*02, *04, *0401, *0402 and *0601), and HLA-DRB1 (*01, *03, *07, *08, *0801, *0803 and *0405). Here, HLA-DRB1 is linked to primary biliary cholangitis.