Since overexpression of c-Jun or C/EBPβ was found to upregulate ETB receptor expression (Figures 1 and 4) immunostaining for c-Jun and C/EBPβ was carried out in retina sections from rats with elevated IOP to determine if these factors are upregulated in vivo in the retina following ocular hypertension. The gene discussed is CEBPB; the disease is ocular hypertension.