F11R and lung carcinoma: In agreement with the MTT results, JAM-A knockdown effectively reduced the capacity of colony formation of the 2 tested lung cancer cell lines (negative control vs. JAM-A siRNA, H1229∶231±19 vs. 55±7, p<0.01; A549∶420±31 vs. 273±21, p<0.01; Fig. 5B).