Patients with CHF had older age (66.7±11.2 years v.s. 62.5±7.8 years, p = 0.037) and higher plasma Nt-proBNP levels (495.4±142.9 pg/mL v.s. 109.1±88.3 pg/mL, p<0.001) than patients without CHF. The gene discussed is NPPB; the disease is congestive heart failure.