Lastly, we compared putative target genes with the set of significantly regulated genes in laser-dissected lung adenocarcinomas of c-Raf-transgenics [n = 370 genes, ref. 28] obtaining a list of 11 genes, i.e. CHST1, CRISPLD2, GATA3, GPC3 HPGD, PCDh1, PRICKLE1, RECK, RUNTX1T1 and SPOCK2. The gene discussed is PRICKLE1; the disease is lung adenocarcinoma.