Basal hyperinsulinemia was associated with a significantly increased insulin/glucose-ratio in SGA-in-SL rats (day 360: AGA-in-NL: 6.4±2.3 vs. SGA-in-NL: 7.6±2.6 vs. SGA-in-SL: 8.5±2.8; day 560: AGA-in-NL: 15.4±6.3 vs. SGA-in-NL: 14.6±5.3 vs. SGA-in-SL: 21.6±11.3; both p<0.05; Figure 2A and 2B). Here, INS is linked to hyperinsulinism.