CCL2 and breast neoplasm: Evidence suggests that RANTES (CCL5), one of the murine homologues of IL8, has angiogenesis-related activities [65]–[68] and CCL2 (JE or MCP-1) is indeed a potent angiogenic chemokine [66], [69]–[73] that acts by increasing the presence of tumor associated macrophages (TAMs) at breast tumor sites, possibly by elevated release of angiogenic factors and by acting directly on endothelial cells to promote angiogenesis.