In examining the cellular heterogeneity of mammary tumors and production of progenitor and stem cell markers in six transgenic models of breast cancer, we found evidence that mammary tumors arising in MMTV-ErbB2 mice may have an origin in more differentiated mammary luminal epithelial cells [55], which probably lack Wnt signaling since Wnt signaling is usually found in stem and early progenitor cells [19]. This evidence concerns the gene ERBB2 and breast carcinoma.