However, there are some reports suggesting that β-catenin activity may play a role in ErbB2+ mammary tumors [50], [52]–[54], while multiple other studies suggest that the Wnt signaling-active subset of breast cells may be especially vulnerable to developing into basal tumors, which exhibit increased Wnt signaling [20], [55], [56]. The gene discussed is ERBB2; the disease is breast cancer.