It has been observed that overexpression of Sirt1 reduces expression of the Angiotensin II Type 1 Receptor (AT1R) (Sunagawa, 2008) and this inhibition seems to prevent endothelial dysfunction of cerebral arterioles (Arrick et al., 2008; Miyazaki et al., 2008). The gene discussed is AGTR1; the disease is endothelial dysfunction.