In human GRK2 levels are increased in myocardial tissue during heart failure (Ungerer et al., 1994; Rengo et al., 2013a,b,c), myocardial infarction (Santulli et al., 2011) and hypertension (Gros et al., 1997; Santulli et al., 2013). This evidence concerns the gene GRK2 and heart failure.