The efficacy of anti-inflammatory medications, such as corticosteroids and adrenocorticotrophic hormone (ACTH), in the treatment of some pediatric epilepsies that do not respond to conventional anticonvulsants was one of the first lines of clinical evidence that epilepsy has an immune inflammatory component (Hrachovy et al., 1983; Mackay et al., 2004). Here, POMC is linked to epilepsy.