CRH and Anxiety: In mammals, fish, amphibians, and reptiles, neurons that express CRF are found throughout the brain in a conserved distribution (Lovejoy and Balment, 1999; Denver, 2009), and CRF signaling has highly conserved effects on arousal and anxiety-related behaviors, locomotion, exploration, and feeding (Koob and Heinrichs, 1999; Bale and Vale, 2004; Lowry and Moore, 2006).