All EpiMods demonstrated strong enrichment for biological terms (Table S11), with the HAND2 EpiMod itself highly enriched for other transcription factors (e.g., GATA4, HEY2, HOXD13, PHOX2A, HAND1), all of which were also hypermethylated in endometrial cancer (Figure S6). This evidence concerns the gene HEY2 and endometrial cancer.