However, we have observed allelic heterogeneity between the IL2RA variants associated with type 1 diabetes and sCD25 concentration [42], and, until much more detailed genetic mapping in larger sample sets is carried out, it will remain unclear if there are causal variants at IL2RA shared between sCD25 concentration and risk of type 1 diabetes and other immune diseases. The gene discussed is IL2RA; the disease is immune system disorder.