Although triacylglycerol accumulation in the liver, as well as in the skeletal muscle, strongly correlates with insulin resistance, it is believed to be just a marker of increased levels of more potent disruptors of insulin signaling, such as fatty acid-derived lipids, which include lysophosphatidic acid (LPA), phosphatidic acid (PA) and diacilglycerol (DAG) [32]. Here, INS is linked to Insulin resistance.