CD40LG and Lyme disease: The calculation of AIs with both the VIDAS Lyme IgG and the recomBead Borrelia IgM and IgG tests requires the analysis of albumin and total IgG (even total IgM for the latter test) in serum and in CSF, which is a disadvantage compared to the IDEIA Lyme Neuroborreliosis assay in terms of cost and ease of use.