By analyzing the expression levels of the Argonaute family member Ago2 in a panel of human hematopoietic cell lines, we observed that Ago2 shows the lowest levels of expression in 2 out of 12 cell lines, that is, the HL60 (AML-M2) and NB4 (AML-M3), exhibiting a myeloblastic and promyelocytic phenotype, respectively35, 36 (Figure 1a; Supplementary Figure S1). The gene discussed is AGO2; the disease is acute myeloid leukemia.