Majority of the fusions in focal amplicons are present on chromosome 7 and restricted to the EGFR locus, see Figure 3 and Figure 4A. Approximately 40% of all the fusions in GBM result from complex genomic rearrangements (CGR), see Figure 4H. Some of the inter-chromosomal rearrangements also display complex fusion mechanisms, see Figure 4G. A recent study analyzed whole genome sequencing data and showed a high incidence of CGR in GBM resulting from chromothripsis—39% in GBM compared to 9% in other tumor types [37]. The gene discussed is EGFR; the disease is glioblastoma.