TARDBP and Huntington disease: IIS reduction was also reported to protect model nematodes from proteotoxicity of other neurodegeneration-linked, aggregative proteins including HD-associated polyQ stretches (Morley et al., 2002) and the amyotrophic lateral sclerosis (ALS)-linked mutated protein, TAR DNA binding protein 43 (TDP-43) (Zhang et al., 2011).