PTGS2 and infectious otitis media: COX-2 protein expression in AOM-induced rat colon carcinogenesis was significantly decreased by 0.38-, 0.102-, and 0.031-fold after treatment with 0.2%, 0.5%, and 1% (w/v) of IP6, respectively, compared with the control group, thus showing a dose-dependent relationship (P < 0.05).