The observed modulatory influences of rice bran IP6 at the level of cell proliferation, by inhibiting β-catenin and COX-2 during AOM-induced CRC, have not been noted previously and suggest that the intake of rice bran IP6 may be used in future clinical chemopreventive trials to monitor the responsiveness of the CRC development to the chemopreventive agents. The gene discussed is PTGS2; the disease is colorectal carcinoma.