WNT3A and colorectal carcinoma: We assumed that IP6 might be involved in regulation or stability of β-catenin level in CRC as a previous study has also reported the role of inositol polyphosphates in Wnt signaling pathway, by which IP5 accumulates in response to Wnt3a, thereby playing an essential component of signaling of the canonical pathway to the level of β-catenin accumulation [47].