A lower activity of hepatic enzymes, such as HMG-CoA reductase and Acyl CoA cholesteryl acyl transferase (ACAT), was demonstrated by Jang et al. in HF-fed hamsters or a higher hepatic cholesterol catabolism, and by Babu & Srinivasan in streptozotocin-induced diabetic rats [22,36]. The gene discussed is HMGCR; the disease is hydrops fetalis.