Despite the minor impact on lipid homeostasis and the lack of effect on adiposity, we have shown that administration of Curcuma longa extract associated with pepper decreased the expression of two important genes (IL6 and TNFα) involved in the induced-HF proinflammatory tone in the subcutaneous adipose tissue, leading back to values similar to the ones observed in animals receiving a standard diet. The gene discussed is TNF; the disease is hydrops fetalis.