Moreover, serum FGF21 levels were not significantly different in subjects with PCOS history (n = 12, median: 109.73 pg/ml; interquartile range: 55.96–174.42 pg/ml) as compared with GDM patients without PCOS history (n = 22, median: 140.41 pg/ml; interquartile range: 82.72–189.50 pg/ml, P>0.05) or controls without PCOS history (n = 56, median: 68.09 pg/ml; interquartile range: 48.38–93.20 pg/ml, P>0.05, Fig 2). Here, FGF21 is linked to gestational diabetes.