On the contrary, serum FGF21 levels were significantly higher in patients with GDM (median: 124.47 pg/ml; interquartile range: 82.72–189.50 pg/ml) than those in controls (median: 68.10 pg/ml; interquartile range: 49.23–97.50 pg/ml; P<0.001). The gene discussed is FGF21; the disease is gestational diabetes.