For example, aldosterone has been implicated in the pathogenesis of pulmonary hypertension [62], and spironolactone has been shown to attenuate experimental pulmonary hypertension via MR inhibition in pulmonary artery smooth muscle cells [63].Admittedly, bleomycin is also a frequently used tool drug to induce pulmonary hypertension [64,65]. The gene discussed is NR3C2; the disease is pulmonary arterial hypertension.