The availability of a HF diet, unexpectedly, led to a decrease in overall caloric intake in PVN Sim1 neuron ablated mice such that their overall caloric intake was (a) significantly decreased relative to their intake on a chow diet and (b) there was no significant difference in intake between them and their iDTR littermates (Figure 5E). The gene discussed is SIM1; the disease is hydrops fetalis.