In human prostatic carcinoma cells, t10,c12-CLA anticancer effect associates to decreased Bcl-2 and increased p21(WAF1/Cip1) mRNA levels [30] while in human colon or bladder cancer cells it was accompanied by the activation of ATF/NAG-1 [31] or Insulin Growth Factor signaling [32]. Here, GDF15 is linked to urinary bladder carcinoma.