EMCN and skin neoplasm: Further, although IL-6 signaling promotes skin tumor growth and angiogenesis in a paracrine fashion [4], we did not detect any difference between KrasG12D and KrasG12D; IL-6-/- mice after immunohistochemical staining with Endomucin, a microvessel density marker to measure angiogenesis index (Figure 1J and K).