Several studies reported that DNMTs are upregulated in thoracic neoplasms, and that those cancers are characterized by global DNA hypomethylation and gene specific hypermethylation (reviewed in 30), and an inverse correlation between DNMT3B levels and global DNA methylation was observed in thymic epithelial tumours [13]. The gene discussed is DNMT3B; the disease is thymic epithelial neoplasm.