FOXO1 and posterior cortical atrophy: To prove this assumption, we (a) studied the influence of miR-96 expression on fundamental cellular characteristics such as proliferation, apoptosis and migration on PCa cell lines, (b) performed in silico target prediction, (c) studied binding of miR-96 to predicted binding sites in the FOXO1 3’ UTR and subsequent changes at the mRNA and protein levels, (d) studied the rescue of FOXO1-induced apoptosis by miR-96 and (e) correlated miR-96 expression with FOXO1 transcript and protein expression in human PCa and matched normal adjacent tissue.