In human colon-derived tumor cells, CD43 signaling leading to cell proliferation has been reported to involve the proteolytic cleavage of the CD43 intracellular domain, its nuclear translocation and interaction with the TCF/LEF1/β-catenin molecular complex, thus resulting in c-Myc and Cyclin D expression [13]. The gene discussed is HNF4A; the disease is neoplasm.