In agreement with data showing that CD43 signals cooperate with the E6/E7 oncoproteins from HPV16 to favor cell transformation (Figure 1E), decreasing CD43 expression levels in the cervical tumor cells line CasKi resulted in approximately 50% reduction in the wound healing capacity (Figure 2B, upper panel) as well as in its anchorage-independent growth capacity (Figure 2B, middle panel), compared with clones expressing normal CD43 levels. The gene discussed is SPN; the disease is uterine cervix neoplasm.