These miRNAs contributed to many essential biological processes, such as TGF-beta signaling pathway, cell cycle, Wnt signaling pathway, MAPK signaling pathway, ErbB signaling pathway, Jak-STAT signaling pathway, and etc. Furthermore, these aberrantly expressed miRNA species were involved in occurrence and development of some human diseases, including chronic myeloid leukemia, pancreatic cancer, colorectal cancer, glioma, prostate cancer, and etc. The gene discussed is EGFR; the disease is prostate carcinoma.