Investigation of the prognostic value of the methylation status of the PLAGL1 promoter CpG island, showed that, as expected, the mean methylation value of the PLAGL1 promoter had no prognostic value in either of these STS sub-types, possibly due to a lack of correlation between mean methylation value of the PLAGL1 promoter and PLAGL1 mRNA expression. The gene discussed is PLAGL1; the disease is telomere syndrome.