Therefore, the aims of this study were 1) to determine the incidence of severe liver tissue lesions (pathological changes) in Chinese patients with HBV or HCV infections, 2) to determine the histologic characteristics of a large cohort of CHB patients undergoing liver biopsy, 3) to understand the relationship between ALT and HBV DNA values obtained at the time of biopsy and liver disease, and 4) to investigate other factors that may be associated with liver disease in this population. This evidence concerns the gene GPT and liver disorder.