CP might cluster in families, and in many of these affected subjects as well as young patients without a family history of pancreatitis, mutations in the genes coding for cationic trypsinogen (PRSS1), pancreatic secretory trypsin inhibitor (SPINK1) and chymotrypsinogen C (CTRC) can be identified [2]–[5]. Here, PRSS1 is linked to pancreatitis.