While FH, which leads to early-onset coronary heart disease, is caused by mutations in the LDL-receptor gene (LDLR), it was shown that heterozygous carriers of the LDLR mutation lived into their eighth and ninth decades in the 19th century but their descendants in the 20th century, who were also heterozygous carriers, lived only into their third and fourth decades [34], [35]. Here, LDLR is linked to coronary artery disorder.