It should also be noted that a susceptibility to PCOS in an association with polymorphisms of ADIPOQ (adiponectin) has been reported [37] and although this observation remains to be confirmed, it does support the view that the influence of PCOS on adiponectin receptor expression and function is independent of the effect of obesity. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.