The combination of specific genetic variants in ORMDL3 and RORA increased the risk for current asthma, with ORs of 2.1 (CI 1.2-3.6) and 3.2 (CI 2.0-5.0) among the BAMSE and PARSIFAL children, respectively (Figure 2 A). The gene discussed is ORMDL3; the disease is asthma.