For example, we found an increased risk for allergic asthma related to a specific combination of genetic variants in RORA and COL29A1, and an increased risk for current asthma related to a specific combination of genetic variants in ORMDL3, RORA and COL29A1. Interestingly, both RORA and ORMDL3 are among the asthma top-hit candidate genes identified by a large GWAS on asthma [6]. The gene discussed is ORMDL3; the disease is allergic asthma.