Intriguingly, β3 promoted TGF-β1/H2O2/HOCl-induced expression of α3 and SNAI2, and also enabled TGF-β1 to augment the promoting effect of H2O2/HOCl on anoikis-resistance, thus promoting TGF-β1/H2O2/HOCl-mediated induction of metastatic phenotype of HCC cells. The gene discussed is SNAI2; the disease is hepatocellular carcinoma.