IGF1 and neoplasm: Treatment of DIO-mice with HI, X10 and IGF-1 also activates the PI3K pathway in MC38 cell allografts and after treatment with X10 and IGF-1 for 14 days, growth of the tumor allografts was significantly increased ≈ 1.5-fold and ≈ 2-fold, respectively, compared to control.