DMac was associated with HbA1c (OR1.48; 95% CI: 1.06–2.06), DM duration (OR 1.16; 95% CI: 1.06–1.26), insulin treatment (OR24.29; 95% CI: 5.02–117.57) and hypertension (OR4.98; 95% CI: 1.06–23.44). This evidence concerns the gene INS and hypertensive disorder.