IL10 and Chagas disease: Since cardiomyocytes are a major target of T. cruzi infection, producing significant levels of NO and cytokines, the treatment with IL-10 using the proper timing, dose and route might exert beneficial effects on the heart, related to its anti-inflammatory effects in the acute phase of Chagas’ disease that, as discussed earlier, may determine the fate of an ongoing inflammatory response with, so far, unpredictable consequences.