The potential mechanisms might be associated with down-regulated expression of TGF-β1, TNF-α, IL-1β, ASK1, NF-κB Bax, up-regulated expression of Bcl-2 and Gata4, activation of eNOS pathway to ameliorate myocardial ischemia, and enhanced cardiac repair. The gene discussed is GATA4; the disease is myocardial ischemia.