Clinical observation has shown increased luteinizing hormone levels in the peripheral blood of PCOS patients [30], acting directly on the luteinizing hormone receptor of theca cells [31], which activates P450C17α activity within theca cells, whereas as a key enzyme in androgen synthesis, P450c17α’s increased activity or expression can promote excessive androgen synthesis, leading to local excessive ovarian androgen or hyperandrogenism in PCOS patients. The gene discussed is LHCGR; the disease is hyperandrogenism.