Although all CH participants were asymptomatic with CDRs of 0, we examined the major AD risk factors of blood pressure, fasting lipids and blood sugar (Table 6), as well as their oft-associated MR biomarkers of SVD (Tables 7 and 8), to investigate the possibility that cryptic cerebrovascular disease might confound our analysis, We found no significant differences between the NAT and PAT subgroups. This evidence concerns the gene BRD2 and Alzheimer disease.